Guest: Windows XP.
In Virtualbox, when you have Windows XP as guest os and you need to reboot in safemode MSconfig utility gives you an option.
- Start Msconfig (Run > msconfig)
- Select the 'BOOT.INI' tab.
- Check the '/SAFEBOOT' option under 'Boot Options'.
- Apply > Ok and reboot.
Un-check the option to boot normally.
Hope that was useful.